What is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme found in all living cells. It plays a critical role in cellular energy metabolism (as a cofactor in redox reactions), DNA repair, cell signaling, and gene expression regulation via sirtuins. NAD+ levels decline with age, and researchers study NAD+ supplementation for its potential role in healthy aging and cellular function.
Research Dosing Parameters
- Typical IV dose range: 250–1000 mg per session (intravenous — not calculated here)
- Typical IM/SC dose range: 25–100 mg per injection
- Common vial size: 500 mg
- Reconstitution: 5–10 mL bacteriostatic water for injection use
- Note: Switch to mg unit in the calculator; doses are large compared to peptides
How to Reconstitute NAD+
- Use sterile bacteriostatic water for subcutaneous/intramuscular use
- Inject water slowly along the vial wall
- Swirl gently until fully dissolved — NAD+ dissolves readily
- Store at 2–8°C; use within 14 days once reconstituted
- Protect from light to prevent degradation
FAQ
Is NAD+ a peptide? Technically, NAD+ is a dinucleotide coenzyme rather than a peptide. However, it is commonly reconstituted and injected similarly to peptides, so it is included here for dosage calculator convenience.
How do I calculate NAD+ injection units? Switch the dose unit to “mg” in the calculator above. Enter your vial size (e.g. 500mg), your BAC water volume, and your target dose (e.g. 50mg) to get exact syringe units.
What is the difference between NAD+ injection and oral NMN/NR supplements? Injectable NAD+ bypasses first-pass metabolism and may achieve higher blood levels more reliably than oral precursors like NMN or NR, though oral forms are more convenient. Research on comparative bioavailability continues.