What is IGF-1 LR3?
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a synthetic, modified form of human IGF-1 with an arginine substitution at position 3 and an additional 13 amino acid extension at the N-terminus. These modifications reduce its binding to IGF-binding proteins (IGFBPs), resulting in a significantly longer half-life (~20–30 hours) compared to native IGF-1 (~12–15 minutes).
Research Dosing Parameters
- Typical dose range: 20–100 mcg per injection
- Common vial size: 1 mg (1000 mcg)
- Reconstitution: 1–2 mL bacteriostatic water (or acetic acid for stability)
- Injection frequency: Daily or post-exercise in research protocols
How to Reconstitute IGF-1 LR3
- IGF-1 LR3 can be reconstituted with dilute acetic acid (0.1%) for better stability, or bacteriostatic water
- Inject the liquid slowly along the vial wall
- Gently swirl — never shake
- Store at 2–8°C; use within 4 weeks
- Protect from light and freeze-thaw cycles
FAQ
What is the difference between IGF-1 LR3 and native IGF-1? IGF-1 LR3 has ~3x lower affinity for IGFBPs and a much longer half-life (~20h vs ~15min), making it a more potent and longer-acting research tool than native IGF-1.
What vial size is typical for IGF-1 LR3? IGF-1 LR3 commonly comes in 1mg vials. Enter 1mg, your BAC water volume, and your target dose (e.g. 50mcg) in the calculator above for exact units.
Should IGF-1 LR3 be reconstituted with acetic acid or BAC water? Research suggests acetic acid (0.1%) may provide better stability. However, the calculator works the same regardless — enter your liquid volume and target dose for accurate results.